Preclinical Comparative Evaluation Study of Sinapic Acid and Curcuminoids on Mouse Model of Depression
Authors: Chetan Ekanath Patel, Dr. Shikha Jaiswal, Dr. Vijay Patel
Keywords: Antidepressants, Neuroprotective, Antioxidant, Integrated behavior.
Abstract:
Preclinical comparative study evaluating the antidepressant potential of Sinapic Acid and Curcuminoids using a validated mice model of depression. Standard behavioral tests are used like the Open Field Test (OFT), Tail Suspension Test (TST), and Sucrose Preference Test (SPT); employed to assess antidepressant effects through integrated behavioral outcomes. Swiss albino mice of both sexes were used and divided into five groups of normal control, disease control, standard Fluoxetine-treated, Sinapic Acid treated, and Curcuminoid-treated groups, with six animals in each group. Treatment drugs were administered for 14 days then followed by post experimental recovery assessment.
Behavioral findings indicated that Sinapic Acid and Curcuminoids attenuated Reserpine-induced depressive symptoms; in the comparative study both treatments significantly improved locomotor activity and reduced grooming behavior in the Open Field Test, decreased immobility time in the Tail Suspension Test, and increased sucrose preference in the Sucrose Preference Test.
This study demonstrates that Sinapic acid and Curcuminoids possess significant antidepressant potential in Reserpine-induced neurobehavioral deficits model by improvement in despair-like behavior and anhedonia; is mediated through antioxidant and neuroprotective mechanisms of phytochemicals. However, further biochemical and molecular investigations are required to elucidate their precise mechanisms of action.
