Indian Journal of Pharmacy and Pharmacology

Page: 92-96

Background: Currently, there is no published scientific evidence regarding the in vitro antiurolithiatic properties of Jasminum officinale root. Therefore, this study represents the first attempt to evaluate the antiurolithiatic activity of the root of Jasminum officinale.

Objectives: The aim of this study was to investigate the In vitro antiurolithiatic activity and preliminary phytochemical screening of the chloroform and ethanolic extracts of Jasminum officinale root.

Methods: Fresh roots of Jasminum officinale were extracted in ethanol and chloroform and arranged in varying quantities. Also studied were the Nucleation, Growth, and Aggregation assays, and the extract was compared to the standard drug Cystone.

Result: Based on the results of the anti-urolithiatic action nucleation, growth, and aggregation assays, the ethanolic extract at 1000 µg/ml demonstrated a greater percentage of inhibition than the standard drug, Cystone.

Conclusion: The root of Jasminum officinale exhibits inhibitory activity on calcium oxalate (CaOx) crystallization, which suggests that its ethanolic and chloroform extracts can have therapeutic significance in the treatment of urolithiasis. These findings justify the conventional use of this plant for treating urinary stone diseases. Nonetheless, to ascertain the clinical utility and safety of Jasminum officinale as an antiurolithiatic drug, additional intensive investigations involving well-designed preclinical experiments and controlled clinical trials are crucial.

Keywords: Jasminum officinale, Antiurolithiatic, Cystone, Nucleation assay, Growth assay