Indian Journal of Pharmacy and Pharmacology
Indian Journal of Pharmacy and Pharmacology (IJPP) is an open-access, peer-reviewed pharmacy journal, published quarterly, as print and online by the Innovative Education and Scientific Research Foundation (IESRF) since 2014. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional membership, and conducting conferences, seminars, and award programs. With the aim of faster and better dissemination of knowledge, we will be publishing articles ‘Ahead of Print’ imm...
Exploring alcohol withdrawal and therapeutic strategies in a tertiary teaching hospital in Nagapattinam
Page: 137-143
Background: Alcohol Withdrawal Syndrome (AWS) is a potentially life-threatening condition that occurs following the sudden cessation of chronic alcohol use. Early identification and symptom-based management are essential to prevent complications such as seizures and delirium tremens.
Objectives: To evaluate the severity of AWS using the CIWA-Ar scale, assess associated clinical and biochemical abnormalities, and examine the therapeutic strategies employed in a tertiary care hospital.
Materials and Methods: A prospective observational study was conducted over six months in the general medicine ward at Government Medical College Hospital, Nagapattinam. A total of 150 male patients diagnosed with AWS were assessed using the CIWA-Ar scale. Laboratory investigations were carried out, and treatment regimens were documented.
Results: Among 150 patients, 77.3% experienced moderate withdrawal symptoms, 21.3% had mild symptoms, and 1.3% presented with severe symptoms. Common symptoms included nausea, sweating, tremors, and anxiety, with agitation and tactile disturbances associated with greater severity. Frequently observed biochemical abnormalities included hyponatremia (12.6%), hypokalaemia (11.3%), and elevated liver enzymes. Benzodiazepines, particularly diazepam (68.6%) and lorazepam (18%), were the primary treatments, alongside thiamine supplementation and supportive care. A significant positive correlation was found between the time since last alcohol intake and symptom severity.
Conclusion: Use of the CIWA-Ar scale facilitates timely, effective treatment in AWS. Structured protocols that include symptom-based pharmacotherapy and correction of biochemical imbalances can improve patient outcomes in tertiary care settings.
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- DOI 10.18231/j.ijpp.67971.1758779418
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- Citation
- Received Date May 28, 2025
- Accepted Date July 05, 2025
- Publication Date September 25, 2025