Indian Journal of Pharmacy and Pharmacology
Indian Journal of Pharmacy and Pharmacology (IJPP) is an open-access, peer-reviewed pharmacy journal, published quarterly, as print and online by the Innovative Education and Scientific Research Foundation (IESRF) since 2014. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional membership, and conducting conferences, seminars, and award programs. With the aim of faster and better dissemination of knowledge, we will be publishing artic...
Current status and future directions of liposomal melatonin in transmucosal delivery systems: Emphasis on the active ingredient from west Bengal Chemical Industries Limited
Page: 206-211
Melatonin (N-acetyl-5-methoxytryptamine) plays a pivotal role in regulating circadian rhythms. It also possesses a significant therapeutic potential due to its antioxidant, anti-inflammatory, and immune-boosting activities. Despite these benefits, the clinical use of melatonin is limited due to its poor oral bioavailability. Liposomal encapsulation has emerged as a promising approach to improve the way melatonin is absorbed in the body. However, oral delivery of liposomal melatonin poses several challenges, which include enzymatic breakdown and incomplete absorption. In this review, we have explored the benefits of combining liposomal encapsulation with oral or sublingual melatonin spray formulations. Both clinical and preclinical studies demonstrate the efficacy of transmucosal sprays, including rapid onset of activity, enhanced bioavailability, and lower dosing. In this review, we have also discussed the potential of West Bengal Chemical Industries Limited (WBCIL) formulated liposomal melatonin to develop next-generation sublingual/oral spray delivery systems designed specifically for children, the elderly, and those with difficulty swallowing.
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- DOI 10.18231/j.ijpp.14872.1769489469
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- Citation
- Received Date December 18, 2025
- Accepted Date January 21, 2026
- Publication Date February 02, 2026