Indian Journal of Pharmacy and Pharmacology
Indian Journal of Pharmacy and Pharmacology (IJPP) is an open-access, peer-reviewed pharmacy journal, published quarterly, as print and online by the Innovative Education and Scientific Research Foundation (IESRF) since 2014. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional membership, and conducting conferences, seminars, and award programs. With the aim of faster and better dissemination of knowledge, we will be publishing artic...
Medicinal investigations of aqueous extract of Nicotiana tabacum L. leaf using biochemical, antimicrobial and green synthesis characterization
Page: 52-61
Background: Tobacco leaf (Nicotiana tabacum L.), historically valued for various applications and has been observed for its medicinal properties.
Objectives: This study aims to investigate the biochemical composition, antioxidant activity, toxicological safety, antimicrobial efficacy, and green synthesis characterization of the aqueous extract of tobacco leaf.
Materials and Methods: Standard analytical methods like Ultraviolet-visible spectrophotometer and Fourier Transform Infra-Red (FTIR) were used in determining the various parameters and their effects on wistar rats.
Results: The results of the analyses revealed the presence of alkaloids, flavonoids, tannins, saponins, and phenolic compounds in the extract. It also exhibited strong antioxidant activities against 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and NO radicals with increased ferric reducing antioxidant power (FRAP) as well as significant levels of total phenols and flavonoids. The sub-acute toxicity analyses indicated no adverse effects from the aqueous extract on the Wistar rats. Hematological and white blood cell analyses in animals orally administered with the extract showed a positive safety profile. Furthermore, the green synthesis of metallic nanoparticles (silver, copper, and zinc) which were characterized using UV-Vis. spectroscopy and FT-IR showed enhanced antimicrobial activity against various pathogenic bacteria and fungi; thus revealed some chemical properties based on the amount of light absorbed as well as identified some organic compounds based on their functional groups.
Conclusion: This study supports the traditional medicinal use of tobacco leaves and suggests their potentials for developing natural antimicrobial agents, nanomedicine and drug development.
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- DOI 10.18231/j.ijpp.14538.1775301581
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- Citation
- Received Date November 25, 2025
- Accepted Date April 04, 2026
- Publication Date April 13, 2026