Indian Journal of Pharmacy and Pharmacology
Indian Journal of Pharmacy and Pharmacology (IJPP) is an open-access, peer-reviewed pharmacy journal, published quarterly, as print and online by the Innovative Education and Scientific Research Foundation (IESRF) since 2014. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional membership, and conducting conferences, seminars, and award programs. With the aim of faster and better dissemination of knowledge, we will be publishing artic...
Exploratory clinical observations of high-dose oral 70 kDa hyaluronan fragments in subcutaneous fat reduction, inflammatory erythema, and facial vitality: A case series
Page: 62-66
Background: The naked mole-rat exhibits unusually high tissue concentrations of hyaluronic acid and minimal subcutaneous adipose tissue, which has stimulated interest in the potential biological roles of HA in tissue homeostasis. This exploratory case series aimed to document clinical observations following high-dose oral administration of 70 kDa HA fragments with respect to perceived changes in subcutaneous fullness, facial erythema, and facial vitality.
Materials and Methods: Eleven Asian participants received oral 70 kDa HA fragments (5 g/day) for 40 consecutive days. Changes in perceived subcutaneous fullness, facial erythema, and facial vitality were evaluated using a modified 0–10 Visual Analog Scale (VAS). Safety and gastrointestinal tolerance were monitored throughout the intervention period.
Results: After 40 days of administration, participants reported varying degrees of perceived reduction in facial and/or body subcutaneous fullness, along with improvements in facial erythema and vitality. Some participants noted visible changes as early as day 7. No adverse events were reported during the intervention period. Incidental improvements in gastrointestinal comfort and dry eye symptoms were also reported by a subset of participants.
Conclusions: High-dose oral 70 kDa HA fragments were well tolerated in this exploratory case series and were associated with self-reported improvements in subcutaneous fullness appearance, facial erythema, and facial vitality. These preliminary observations warrant further investigation in larger controlled studies incorporating objective measurements.
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- DOI 10.18231/j.ijpp.16021.1773815689
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- Citation
- Received Date March 18, 2026
- Accepted Date March 22, 2026
- Publication Date April 13, 2026