Indian Journal of Pharmacy and Pharmacology
Indian Journal of Pharmacy and Pharmacology (IJPP) is an open-access, peer-reviewed pharmacy journal, published quarterly, as print and online by the Innovative Education and Scientific Research Foundation (IESRF) since 2014. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional membership, and conducting conferences, seminars, and award programs. With the aim of faster and better dissemination of knowledge, we will be publishing artic...
To compare the efficacy and safety of eperisone with thiocolchicoside in patients with acute lower backache associated with muscle spasm
Page: 79-83
Background & Objectives: Eperisone hydrochloride is a new drug came in market with centrally acting muscle relaxant, having additional vasodilator effect and used for treatment of backache associated with muscle stiffness like thiocolchicoside but supposed to be slightly better in efficacy and adverse effect profile. The aim of this study was to compare the efficacy and safety of eperisone with thiocolchicoside in patients with acute lower backache associated with muscle spasm.
Methods: 100 eligible subjects were taken and assessment of severity of pain and muscle spasm was done by using Visual Analogue Scale, finger-to-floor distance (FFD), Lasegue’s maneuver and modified Schober’s test.
Results: No statistically significant difference in pain relief and muscle spasm among both the treatment groups but clinically pain relief is slightly better in eperisone group. The adverse drug reactions occurring during study showed a slightly better safety profile in patients on eperisone than on thiocolchicoside.
Conclusion: These findings confirm that eperisone represents a valuable and safer alternative to thiocolchicoside for treatment of low back pain associated with muscle spasm.
Keywords: Eperisone, Low backache (LBP), Muscle relaxants, Visual Analogue Scale (VAS), Thiocolchicoside
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- Received Date November 30, -0001
- Accepted Date November 30, -0001
- Publication Date February 09, 2021