Indian Journal of Pharmacy and Pharmacology
Indian Journal of Pharmacy and Pharmacology (IJPP) is an open-access, peer-reviewed pharmacy journal, published quarterly, as print and online by the Innovative Education and Scientific Research Foundation (IESRF) since 2014. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional membership, and conducting conferences, seminars, and award programs. With the aim of faster and better dissemination of knowledge, we will be publishing artic...
Aluminium chloride catalyzed one-pot synthesis of 2-aryl substituted benzimidazoles and their antibacterial activity
Page: 198-202
2-aryl substituted benzimidazole derivatives were synthesized by using various aromatic aldehydes contains electron releasing as well as electron withdrawing groups, o-phenylenediamine and aluminium chloride as a catalyst via one-pot reaction by use of water as ecological solvent. This route provides an ecological, uncomplicated develops and give compounds in high yield. The synthesized 2-aryl substituted benzimidazole derivatives were characterized by physical (molecular weight, molecular formula, melting point, recrystallization, Rf value) and spectral data (IR and (1)H-NMR). All the synthesized compounds were evaluated for their in-vitro antibacterial activity against few gram-positive and few gram-negative microorganisms.
Keywords: o-Phenylenediamine, Aluminium chloride, Aromatic aldehydes, 2-Aryl substituted benzimidazole derivatives, Antibacterial activity
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- Publication Date January 04, 2021