Indian Journal of Clinical Anatomy and Physiology
Indian Journal of Clinical Anatomy and Physiology (IJCAP) is an open access, peer-reviewed medical quarterly journal, published since 2014 under the auspices of the Innovative Education and Scientific Research Foundation (IESRF), which aims to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional memberships, and conducting conferences, seminars, and award programs....
IN VITRO CONTRACTILE STUDY FROM EXCISED HUMAN GASTROINTESTINAL SPECIMENS: AN IMPORTANT TOOL FOR UNDERSTANDING MECHANISMS OF MOTILITY DISORDERS
Page: 89-91
It is well known fact that enteric nervous system plays a major role in regulation of contractile functions of intestinal smooth muscle. A number of neurotransmitters (excitatory/inhibitory) including Acetylcholine (ACh), Histamine, Serotonin, NO, Substance P, Bombesin, Motilin, ATP, VIP, Met-encephalin and Leu-encephalin, Polypeptide Y, Somatostatin are involved in gastrointestinal (GIT) motility mechanism. They are secreted by different neurons of enteric nervous system to modulate contractile and secretory functions of GIT. Dysregulation of some of these transmitters or their receptors have been already implicated in pathophysiology of certain GIT motility disorders. The present paper discusses how an in vitro study on diseased excised specimens may be useful in understanding the pathophysiology of various motility related GIT problems and thereby may be helpful for better medical and surgical management.
Keywords: In vitro study, Gastrointestinal motility, Smooth muscle contraction, Neurotransmitters, Enteric nervous system
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- Received Date November 30, -0001
- Accepted Date November 30, -0001
- Publication Date March 03, 2021